|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS).
|
19183934 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years.
|
20578204 |
2010 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
We have confirmed TCF7L2 to be a diabetes locus in a large case-control study in Tayside, UK.
|
17429603 |
2007 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped four single nucleotide polymorphisms (SNPs) of TCF7L2 (rs7901695, rs7903146, rs11196205 and rs12255372) in 831 subjects with diabetes and 437 control subjects.
|
18291022 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We assessed five single nucleotide polymorphisms (SNPs) in TCF7L2 including the putative SNP (rs7903146) for diabetes.
|
18268068 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We analysed the recently reported type 2 diabetes (T2D) associated polymorphisms in the TCF7L2 gene using a case-control approach, under the hypothesis that TCF7L2 variants should show similar association if diabetes in FCPD is similar to T2D.
|
18706099 |
2008 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.
|
22872755 |
2012 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To further determine whether variation in Tcf7l2 expression may lead to diabetes, we developed a Tcf7l2 copy-number allelic series in mice.
|
21673050 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thus, diabetes-associated TCF7L2 gene variation predicts the success of lifestyle intervention in terms of weight loss and determines individual susceptibility toward environmental factors.
|
20028944 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia.
|
22441719 |
2012 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study indicates that variants in the TCF7L2 gene significantly contribute to diabetes susceptibility in African-American populations.
|
17601994 |
2007 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population.
|
27465520 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes incidence in the DESIR cohort.
|
17977958 |
2008 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings suggest that TCF7L2 is a central node in the regulation of human diabetes and other disease-associated genes.
|
20640398 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These data provide evidence that the beneficial effect of whole-grain intake on diabetes risk is modified by TCF7L2 rs7903146.
|
19149908 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2.
|
31691451 |
2020 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The transcription factor TCF7L2 is particularly strongly associated with risk for diabetes and appears to be fundamentally important in both canonical Wnt signaling and beta-cell functioning.
|
20217507 |
2010 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The transcription factor 7-like 2 (TCF7L2) gene confers one of the strongest genetic predispositions to type 2 diabetes, but diabetes development can be modified by diet.
|
31049566 |
2019 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The Role of TCF7L2 rs7903146 in Diabetes After Kidney Transplant: Results From a Single-Center Cohort and Meta-Analysis of the Literature.
|
26555947 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the TCF7L2 rs11196172 polymorphism increases the risk of CRC independently, with no evidence of an interaction with diabetes or obesity.
|
27792933 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The population attributable risks for diabetes with TCF7L2 risk alleles were 15 % and with diabetes in a first-degree relative 31 %.
|
18972257 |
2009 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The frequency of diabetes-associated TCF7L2 genotypes was greater in cases ascertained for positive family history and early onset (rs4606565, P = 0.02); the population-attributable risk, estimated from the least-selected cases, is approximately 16%.
|
16936215 |
2006 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin:insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production.
|
21814547 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to elucidate which variant in TCF7L2 confers diabetes susceptibility in African Americans.
|
20980453 |
2011 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to ascertain the polymorphic markers profile of ADIPOQ, KCNJ11 and TCF7L2 genes in Kyrgyz population and to analyze the association of polymorphic markers and combinations of ADIPOQ gene's G276T locus, KCNJ11 gene's Glu23Lys locus and TCF7L2 gene's VS3C>T locus with type two diabetes (T2D) in Kyrgyz population.
|
30467975 |
2019 |